Why the study?
Does CGS 30440 improve renal protective effects compared to benazepril in a model of chronic renal failure?
Population
Model of five-sixths nephrectomy (chronic renal failure)
Comparison
CGS 30440 at 6.5 micromol/kg/day or 2.2… vs Benazepril at 6.5 micromol/kg/day or 2.2…
Design
Preclinical
Follow-up
6 weeks
Authors
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Should not yet change practice; extends preclinical evidence for dual ACE/NEP inhibition in chronic renal failure models.
Does CGS 30440 improve renal protective effects compared to benazepril in a model of chronic renal failure?
A combined ACEI/NEPI (CGS 30440) provided greater renal protection than ACE inhibition alone in a preclinical model of chronic renal failure.
Cohen et al. (1998) studied this question.
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