May 1, 1991The Journal of Clinical Endocrinology & Metabolism

A Study of the Serum Concentration of Tumor Necrosis Factor-α in Thyroidal and Nonthyroidal Illnesses*

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Why the study?

Does serum TNF-alpha correlate with thyroid hormone levels in patients with nonthyroidal illnesses?

Population

48 subjects including normal subjects, patients with nonthyroidal illnesses, hyperthyroidism, and…

Design

Cross-sectional

Authors

ICINDER J. CHOPRATufts University SSSadaki SakaneMunicipal Hirakata City Hospital GTGUADALUPE N. CHUA TECOOklahoma State University Center for Health Sciences

Discussion

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Implication

TNF-alpha may contribute to free T4 changes in NTI; hypothesis-generating and should not alter management.

Structured PICO

Does serum TNF-alpha correlate with thyroid hormone levels in patients with nonthyroidal illnesses?

Population

48 subjects including normal subjects (n=16), patients with nonthyroidal illnesses (NTI; n=13), hyperthyroidism (n=10), and hypothyroidism (n=9).

Outcome

Serum concentrations of TNF-alpha and iodothyronines (T4, T3, and rT3) and their correlationssurrogate

Circulating TNF-alpha may contribute to elevated free T4 in nonthyroidal illnesses, but it is not a universal factor in the pathogenesis of euthyroid sickness syndrome.

Cite This Study

CHOPRA et al. (1991) studied this question.

synapsesocial.com/papers/6a7c1dcda540d02696c2c4fc https://doi.org/10.1210/jcem-72-5-1113

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A Study of the Serum Concentration of Tumor Necrosis Factor-α in Thyroidal and Nonthyroidal Illnesses*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Study of the Serum Concentration of Tumor Necrosis Factor-α in Thyroidal and Nonthyroidal Illnesses*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider