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A reversibly coordinating auxiliary is the key to the first highly diastereo-selective hydroformylation of acyclic methallylic alcohols (syn:anti up to 96:4; in the representation on the right the auxiliary is shown as a sphere). The reaction can be used for the efficient construction of stereotriades, the central structural units of polyketide natural products. R is, for example, Ph, CO2Me, Me, CH2Ph.
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Bernhard Breit (1996) studied this question.
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