Addition of organometallic reagents to nitriles promoted by titanium(IV) isopropoxide as a procedure of synthesis of primary tert-alkylamines

Grignard reagents are able to add twice to nitriles in the presence of titanium(IV) isopropoxide providing primary tert -alkylamines in a fair yield. The conditions and structural features of reagents required for successful reaction were established. A possibility to apply two different organometallic reagents was demonstrated, in particular, the use of organolithium compounds in the second stage.