Case report demonstrates dual-tracer PET/CT improves localization of tumor-induced osteomalacia in rare phosphaturic mesenchymal tumor, suggesting better outcomes.
Phosphaturic mesenchymal tumor (PMT) is a rare cause of tumor-induced osteomalacia (TIO), often presenting with nonspecific symptoms and small tumor size, leading to diagnostic challenges. We report a case of a 25-year-old male with progressive generalized bone pain, hypophosphatemia, and elevated alkaline phosphatase, initially misdiagnosed as spondyloarthritis and osteoporosis. Whole-body bone scintigraphy suggested metabolic bone disease. 18 F-FDG PET/CT revealed a destructive lesion in the mandible with moderate uptake, whereas ⁶⁸Ga-DOTATATE PET/CT showed high somatostatin receptor expression, accurately localizing the PMT. Serum phosphate levels normalized rapidly after surgical resection. This case highlights the superior diagnostic value of ⁶⁸Ga-DOTATATE PET/CT over 18 F-FDG PET/CT in localizing PMT, facilitating targeted treatment and avoiding prolonged morbidity.
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Ye et al. (2026) studied this question.
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