In a guinea-pig model, left ventricular hypertrophy induced by aortic constriction leads to decreased intracellular pH and a secondary increase in H+ buffering capacity.
Suggests pH dysregulation in hypertrophy; hypothesis-generating in animal models and should not change practice.
Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units in hypertrophied hearts). Intracellular H+ buffering capacity (beta) increased as pHi fell, but the value of beta was independent of hypertrophy per se.
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Wallis et al. (1997) studied this question.
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