Evaluates how temperature and humidity affect handling of OTC soft capsules, indicating significant implications for product usability.
We investigated the impact of temperature and humidity on the convenience of handling over-the-counter (OTC) soft capsule drugs. Following a report of capsule rupture and liquid leakage in Product A, we performed controlled experiments using five products, including Product A. Capsules in the press-through packaging were stored under various conditions (20℃ or 35℃; high or low humidity) and evaluated for elongation rate under pressure, rupture rate, moisture absorption, and ease of removal from press-through packaging.
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Habu et al. (2026) studied this question.
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