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August 12, 2026Journal of Child Psychology and Psychiatry

The effect of atomoxetine and methylphenidate on emotional dysregulation in children with attention deficit/hyperactivity disorder: a multicenter randomized clinical trial

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Authors

YGYuan GaoZWZhao-Min Wu杨杨斌让

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Overview

Randomized trial compares atomoxetine and methylphenidate effects on emotional dysregulation in children with ADHD, indicating significant treatment benefits.

Key Points

  • This study aims to compare the effects of atomoxetine and methylphenidate on emotional dysregulation in children with ADHD.
  • 152 children with ADHD were randomly assigned to receive atomoxetine (N=76) or methylphenidate (N=76) for 4 weeks.
  • Emotional lability was the primary outcome, with mixed-effects linear models used for analysis.
  • Functional MRI data were collected and analyzed at baseline and endpoint using whole-brain connectivity analysis.
  • Emotional lability scores decreased significantly over time in both treatment groups (β = −1.54, p < .001), with no significant between-group difference.
  • After controlling for ADHD symptom improvement, treatment effects remained significant (β = −0.75, p < .001).
  • Increased functional connectivity between specific amygdala regions was associated with emotional lability changes.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/6a7c208206a85aed514b750fhttps://doi.org/10.1111/jcpp.70217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Emotional problems and dysregulation in children/youth with <scp>ADHD</scp> : predictive and moderating effects in a randomized controlled trial of methylphenidate and neurofeedback2026
  2. 2The Efficacy of Methylphenidate Use in Children Diagnosed With Attention Deficit Hyperactivity Disorder With Emotional Impulsivity Symptoms2025
  3. 3Pharmacological interventions for emotional dysregulation in ADHD: a meta-analysis stratified by sex and ADHD subtypes2025 · 4 citations
  4. 4Methylphenidate for Emotional Dysregulation in patients with Comorbid ADHD and Borderline Personality Disorder2025
  5. 5Emotion Dysregulation in Adolescents Is Normalized by ADHD Pharmacological Treatment2024