Demonstrates formal total synthesis of crispine A using asymmetric cycloaddition, highlighting innovative synthetic methods.
We report herein the formal total synthesis of crispine A. The key feature of our synthetic route is an asymmetric formal [3+2] cycloaddition between cyclic nitrones and Meldrum’s acid using a quinine-derived chiral amine-urea. The cycloaddition provided an optically active isoxazolidinone, which was successfully converted to a common precursor of crispine A.
No takes yet. Share an insight, caveat, or question.
Toda et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: