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August 12, 2026Chinese Medical JournalOpen Access

Delayed antiviral immune response in alveolar type 2 cells increases susceptibility to influenza virus in alveoli

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Authors

XSXiao ShangZWZeyi WangJYJiapei Yu

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Overview

Randomized trial investigates antiviral responses in alveolar cells, revealing increased infection vulnerability in AT2 cells.

Key Points

  • This research aims to understand the differences in susceptibility and antiviral responses between alveolar type 1 and type 2 cells during influenza virus infection.
  • Immunofluorescence staining used to examine influenza A virus distribution.
  • Primary murine epithelial cell cultures for AT1 and AT2 cells were established.
  • Bulk RNA sequencing and quantitative polymerase chain reaction characterized antiviral responses.
  • Mouse AT2 cells showed higher susceptibility to H1N1 than AT1 cells.
  • In vitro models reproduced in vivo cellular responses with higher viral replication in AT2 cells.
  • AT1 cells displayed enriched gene responses for antiviral processes compared to AT2 cells.

Cite This Study

Shang et al. (2026) studied this question.

synapsesocial.com/papers/6a7c20a306a85aed514b78d7https://doi.org/10.1097/cm9.0000000000004107
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