Why the study?
Does renal transplantation improve blood pressure and left ventricular hypertrophy in pediatric patients?
Does renal transplantation improve blood pressure and left ventricular hypertrophy in pediatric patients?
Renal transplantation in pediatric patients is associated with a significant improvement in left ventricular hypertrophy, despite persistent or worsening hypertension.
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Hypothesis-generating for LVH regression after pediatric renal transplant despite hypertension; prospective studies needed before practice implications.
This study was conducted to evaluate the changes in BP and LVH after the transplantation and to evaluate the effect of BP changes in LVH. Forty-three pediatric renal transplant patients, with a mean age of 16.99 ± 3.88 years, were enrolled in this study. Twenty-three (53.5%) of the patients were male. Medical records for pretransplantation period (closest to the time of transplantation) and for post-transplantation period (9-12 months after transplantation) were reviewed. All the patients had BP measurements and echocardiographic evaluation in pre- and post-transplantation period. Hypertension was defined as an average systolic and/or diastolic BP that is ≥95th percentile for sex, age, and height. Although the number of patients with hypertension increased from 30 (69.76%) to 35 (81.4%), the number of patients with LVH decreased from 19 (44.1%) to 9 (20.9%) after the transplantation. Although the only significant difference in BP measurements was between the mean Z scores of 24 hour and nighttime mean DBP before and after the transplantation; the mean LVMI, and the prevalence of LVH was significantly lower after the transplantation. There was no significant correlation between the LVMI and the BP measurements. Even though hypertension may persist, there is significant improvement in LVH after renal transplantation.
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Ramoğlu et al. (2017) studied this question.
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