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Fluoro-isosteres of natural products containing hexahydropyrazino[1′,2′-1,5]pyrrolo[2,3-b]indole-1,4-dione moieties are readily prepared by FP-T300-mediated fluorination–cyclization of cyclo-Trp-AAs (Trp=tryptophan, AA=amino acid). Isosteres 1 b and 2 b of gypsetin (1 a) and brevianamide E (2 a), respectively, were thus synthesized.
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Shibata et al. (2001) studied this question.
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