Elevated CPK-MB in the setting of normal total CPK and myoglobin can indicate myocardial involvement in acute pericarditis without implying acute myocardial infarction.
Hypothesis-generating for biomarker patterns distinguishing pericarditis from MI; prospective validation required before diagnostic use.
An elevated level of the MB fraction of creatine phosphokinase (CPK) with normal serum myoglobin and normal CPK values was found in a case of acute idiopathic pericarditis. The elevated serum CPK-MB isozyme is suggested to be an indicator of myocardial involvement accompanying acute pericarditis. The normal CPK and serum myoglobin values and the pattern of rapid decrease of CPK-MB level ruled out the possibility of acute myocardial infarction.
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Alon Marmor (1979) studied this question.
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