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July 1, 2026Diabetes and Vascular Disease ResearchOpen Access

Analysis of the diabetic arterial transcriptome to define novel biomarkers of macrovascular disease

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Authors

ASAya ShoumaMGMarilena GiannoudiMCMarcella Conning-Rowland

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Overview

Cohort study reveals arterial protein biomarkers linked to vascular events in diabetes, highlighting improved cardiovascular risk prediction.

Key Points

  • Identify differentially expressed genes in diabetic arteries to uncover circulating biomarkers that improve atherosclerotic cardiovascular disease risk prediction.
  • Analyzed RNA-sequencing data from the thoracic aorta and tibial artery of >90 individuals with diabetes mellitus and >330 controls to identify differentially expressed genes.
  • Used UK Biobank plasma proteomics data to validate circulating protein forms of overlapping genes and assess their association with incident atherosclerotic cardiovascular events.
  • Incorporated validated proteins into SCORE2 and SCORE2-Diabetes risk algorithms to evaluate model discrimination, classification, and calibration.
  • Identified 619 thoracic aorta and 356 tibial artery differentially expressed genes associated with diabetes mellitus, with 22 concordant genes shared across both arterial sites.
  • Corroborated four plasma proteins (ACP5, LEFTY2, LILRA5, and PSME2) showing concordant differential abundance in diabetes and significant associations with incident cardiovascular events.
  • Adding the four proteins to SCORE2 and SCORE2-Diabetes models improved population-level discrimination, classification, and calibration of cardiovascular risk.

Cite This Study

Shouma et al. (2026) studied this question.

synapsesocial.com/papers/6a7c2a31050daa66a5df7f64https://doi.org/10.1177/14791641261474099
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Also Consider

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