Chronic Partial Occlusion of the Pulmonary Artery in Cats
Population
Cats subjected to partial pulmonary artery occlusion or sham operation
Comparison
Chronic right ventricular outflow tract… vs Sham operation
Design
Preclinical
Follow-up
1, 3, 7, 10, 21, and > 90 days after surgery
Authors
Discussion
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Implication
Early force deficits in pressure-overloaded feline ventricles warrant mechanistic follow-up; leaves open translation to human hypertrophy or failure.
Structured PICO
P
Population
Cats subjected to partial pulmonary artery occlusion or sham operation
I
Intervention
Chronic right ventricular outflow tract obstruction via partial pulmonary artery occlusion
C
Comparator
Sham operation
O
Outcome
Transmembrane potentials and isometric active force at optimal length (Po) in isolated right ventricular papillary muscles and trabeculae carneaesurrogate
In a feline model of pressure overload, early right ventricular hypertrophy is associated with transient alterations in action potential configuration and sustained decreases in active force generation.
Cite This Study
Bassett et al. (1973) studied this question.