Why the study?
Statins demonstrate anti-inflammatory pleiotropic effects, but their inflammatory and immunomodulatory properties needed evaluation in subjects at low-to-moderate cardiovascular risk.
Does rosuvastatin 20 mg per day alter inflammatory and immunomodulatory markers in subjects at low-to-moderate cardiovascular risk?
Does rosuvastatin 20 mg per day alter inflammatory and immunomodulatory markers in subjects at low-to-moderate cardiovascular risk?
Rosuvastatin 20 mg daily reduces C-reactive protein but increases vascular endothelial growth factor and epidermal growth factor in patients with low-to-moderate cardiovascular risk, suggesting complex immunomodulatory effects.
Rosuvastatin was associated with lower CRP in low-risk subjects; hypothesis-generating for pleiotropic effects, requires RCT confirmation before practice change.
Statins have shown anti-inflammatory pleiotropic effects in subjects with/at risk of cardiovascular disease. The aim of this study was to evaluate the inflammatory/immunomodulatory properties of rosuvastatin in subjects at low-to-moderate cardiovascular risk. Data was collected from patients’ records, physical examination and blood sampling. Subjects were assigned to rosuvastatin 20 mg per day. Rosuvastatin significantly decreased C-reactive protein ( p = 0.045), and increased vascular endothelial growth factor ( p = 0.004) and epidermal growth factor ( p = 0.009). A multivariate analysis identified total cholesterol ( p = 0.027) and vascular endothelial growth factor ( p = 0.011) to be independently associated with rosuvastatin treatment. Given beneficial/harmful role of growth factors, vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), in cardiovascular disease, one would suggest the need for routine monitoring of growth factor levels, especially in patients on long-term statin therapy.
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Vavlukis et al. (2021) studied this question.
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