What question did this study set out to answer?

Summarize the clinical features, epidemiology, and underlying biological mechanisms of acute respiratory distress syndrome to guide translational therapies.

January 16, 2015The Journal of ImmunologyOpen Access

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

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Authors

SHSeungHye HanNorthwestern University RMRama K. MallampalliThe Ohio State University

Discussion

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Implication

Narrative review outlines molecular drivers of acute respiratory failure, highlighting innate immunity and aberrant proteolysis as promising therapeutic targets.

Key Points

Summarize the clinical features, epidemiology, and underlying biological mechanisms of acute respiratory distress syndrome to guide translational therapies.
Synthesized clinical and preclinical literature addressing acute respiratory distress syndrome definitions, epidemiology, and pathophysiological pathways.
Evaluated molecular mechanisms of inflammatory injury to the alveolar capillary barrier, focusing on innate immunity, damage signaling, and proteolytic processes.
Identified disruption of the alveolar capillary barrier and extravasation of protein-rich edema into the alveolar airspace as core pathological drivers of severe hypoxemic respiratory failure.
Characterized dysregulated innate immune pathways, cellular damage signals, and aberrant proteolysis as critical mechanisms that offer viable targets for disease-modifying therapies.

Cite This Study

Han et al. (2015) studied this question.

synapsesocial.com/papers/6a7c3769c2a640f0bcdf9d38 https://doi.org/10.4049/jimmunol.1402513

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January 16, 2015The Journal of ImmunologyOpen Access

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

View Full Paper

Ask AI

Bookmark

Authors

SHSeungHye HanNorthwestern University RMRama K. MallampalliThe Ohio State University

Discussion

Member takes

Implication

Narrative review outlines molecular drivers of acute respiratory failure, highlighting innate immunity and aberrant proteolysis as promising therapeutic targets.

Key Points

Summarize the clinical features, epidemiology, and underlying biological mechanisms of acute respiratory distress syndrome to guide translational therapies.
Synthesized clinical and preclinical literature addressing acute respiratory distress syndrome definitions, epidemiology, and pathophysiological pathways.
Evaluated molecular mechanisms of inflammatory injury to the alveolar capillary barrier, focusing on innate immunity, damage signaling, and proteolytic processes.
Identified disruption of the alveolar capillary barrier and extravasation of protein-rich edema into the alveolar airspace as core pathological drivers of severe hypoxemic respiratory failure.
Characterized dysregulated innate immune pathways, cellular damage signals, and aberrant proteolysis as critical mechanisms that offer viable targets for disease-modifying therapies.

Cite This Study

Han et al. (2015) studied this question.

synapsesocial.com/papers/6a7c3769c2a640f0bcdf9d38 https://doi.org/10.4049/jimmunol.1402513

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