Answers are grounded in this paper and cite their sources.
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE). The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be the most effective inhibitors of the enzyme. These compounds are highly specific in their inhibitory activity.
No takes yet. Share an insight, caveat, or question.
Groutas et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: