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A clinical trial was commenced in 1968 on the Island of Lewis, Scotland, to evaluate the effects of a new dentifrice formulation containing, as its main active ingredient, 2% monofluorophosphate. The trial design conformed to international protocol and three age groups of children, namely, 5‐year‐olds, 8‐year‐olds and 11‐year‐olds, participated for a three‐year period. The results show that the dentifrice is an effective anti‐caries agent and the magnitude of its effects is generally greater than reported in studies of other dentifrice products.
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Hargreaves et al. (1973) studied this question.
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