Key result
Dexmedetomidine-ketamine resulted in a significantly longer recovery time (mean 48 minutes) compared to propofol-ketamine (mean 39 minutes) in pediatric patients undergoing cardiac catheterization.
Why the study?
Does dexmedetomidine-ketamine compared to propofol-ketamine improve recovery time and hemodynamics in pediatric patients undergoing cardiac catheterization?
Population
59 pediatric patients undergoing cardiac catheterization for evaluation and intervention of congenital heart…
Comparison
Dexmedetomidine 1 µg/kg over 10 minutes… vs Propofol 50 µg/kg/min by infusion, following…
Design
RCT, Randomly divided into 2 groups of 30 each using closed envelope method
Follow-up
Until recovery (modified Steward score ≥6)
Authors
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Propofol-ketamine shortens recovery versus dexmedetomidine-ketamine in pediatric cardiac catheterization; extends RCT evidence favoring propofol-based sedation for procedural efficiency.
RCT (n=59)
closed envelope method
No
Does dexmedetomidine-ketamine compared to propofol-ketamine improve recovery time and hemodynamics in pediatric patients undergoing cardiac catheterization?
Absolute Event Rate: 48% vs 39%
p-value: p=<0.05
Both dexmedetomidine-ketamine and propofol-ketamine are suitable for pediatric cardiac catheterization, though propofol-ketamine provides a significantly shorter recovery time.
Ali et al. (2015) conducted an RCT in Congenital heart disease (n=59). Dexmedetomidine-ketamine vs. Propofol-ketamine (Propofol 50µg/kg/min infusion following ketamine 1mg/kg bolus) was evaluated on Recovery time (time to reach a modified Steward score of ≥6) (p=<0.05). Dexmedetomidine-ketamine resulted in a significantly longer recovery time (mean 48 minutes) compared to propofol-ketamine (mean 39 minutes) in pediatric patients undergoing cardiac catheterization.
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