Key result
Long-term antidepressant use increased substantially, accounting for 43.7% of use in 2005-2015 compared to 30.3% in 1995-2005.
Population
156,620 patients in routine general practice care in and around Amsterdam, The Netherlands
Design
Cohort
Follow-up
1995-2015
Authors
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Rising long-term antidepressant use warrants periodic clinical review in primary care; leaves open appropriateness and outcomes in observational data.
Cohort (n=156,620)
Absolute Event Rate: 43.7% vs 30.3%
Long-term antidepressant use in general practice is substantial and has increased significantly over a 20-year period, driven by factors like older age and SSRI/SNRI use.
Huijbregts et al. (2017) conducted a cohort in Antidepressant use (n=156,620). Antidepressant use vs. 1995-2005 period was evaluated on Prevalence of long-term antidepressant use. Long-term antidepressant use increased substantially, accounting for 43.7% of use in 2005-2015 compared to 30.3% in 1995-2005.
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