Key result
Poor medication adherence may explain some of the increased risk of adverse clinical outcomes associated with depression after acute coronary syndrome.
Why the study?
Does poor medication adherence explain the increased risk of adverse clinical outcomes in depressed patients after acute coronary syndrome?
Does poor medication adherence explain the increased risk of adverse clinical outcomes in depressed patients after acute coronary syndrome?
Poor medication adherence may explain some of the increased risk of adverse clinical outcomes in depressed patients after acute coronary syndrome.
Hypothesis-generating for adherence as mediator in depressed post-ACS patients; prospective trials needed before practice change.
In survivors of acute coronary syndromes (ACS; unstable angina or myocardial infarction), depression is highly prevalent [1] and increases the risk of adverse medical outcomes, independent of other prognostic risk markers [2, 3] . After ACS, adherence to recommended medications (e.g. aspirin, statins and -blockers) is crucial to prevent recurrent events or mortality [4–6], yet rates of adherence to these medications are poor [7–9] . Depressed patients are especially likely to be poorly adherent [8–11] . Thus, poor medication adherence may explain some of the increased risk of depression and adverse clinical outcomes after ACS.
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Rieckmann et al. (2011) studied Acute Coronary Syndrome. Depression and poor medication adherence was evaluated. Poor medication adherence may explain some of the increased risk of adverse clinical outcomes associated with depression after acute coronary syndrome.
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