Key result
Ischemic postconditioning confers cardioprotection in MI and cardiac surgery, but aging and metabolic syndrome attenuate efficacy.
Answers are grounded in this paper and cite their sources.
Analysis of experimental data indicates that aging, metabolic syndrome may be serious obstacle against realization of cardioprotective effect of postconditioning. The moderate hypercholesterolemia, postinfarction cardiosclerosis and cardiac hypertrophy do not abolish protective effect of postconditioning in experimental animals. The issue whether diabetes mellitus and arterial hypertension affect an efficacy of postconditioning is a subject of discussion. Clinical investigations testify on cardioprotective impact of postconditioning in patients with acute myocardial infarction and cardiosurgery patients. At the same time, it is remained unclear when after coronary artery occlusion postconditioning exhibits cardioprotective effect. It is remained unknown how do affect aging, diabetes mellitus, metabolic syndrome, arterial hypertension, myocardial hypertrophy, cardiac postinfarction remodeling and efficacy postconditioning in clinical praxis. It is required a further clinical investigations turning the development pharmacological approaches to prophylaxis of reperfusion injury of the heart.
No takes yet. Share an insight, caveat, or question.
Маслов et al. (2013) conducted a review in Acute myocardial infarction and reperfusion injury of the heart. Ischemic postconditioning was evaluated on Cardioprotective effect against reperfusion injury. Ischemic postconditioning shows cardioprotective effects in acute myocardial infarction and cardiac surgery, though aging and metabolic syndrome may hinder its efficacy (no statistics reported).
Synapse has enriched 10 related papers. Consider them for comparative context: