Population
Poliovirus type 1, strain Mahoney (PVM) and HeLa R19 cells
Comparison
Mutations in the cysteine-rich motif of… vs Wild-type poliovirus protein 2C ATPase
Design
Preclinical
Authors
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May guide antiviral development targeting 2C ATPase; leaves open translation from poliovirus models to clinical use.
The cysteine-rich motif in poliovirus protein 2C ATPase is essential for viral RNA replication and binds zinc in vitro, though zinc binding is not required for ATP hydrolysis.
Pfister et al. (2000) studied this question.