Key result
Human Enterovirus 71 (EV-A71) neutralizing antibodies were detected in 56.7% of healthy individuals in Iran, with seropositivity significantly increasing with age.
Why the study?
Human Enterovirus 71 causes dermal to neurological diseases and polio-like paralysis outbreaks worldwide, but seroepidemiological data in Iran were lacking.
Cross-Sectional (n=547)
No
This first seroepidemiological study in Iran demonstrates a 56.7% seroprevalence of EV-A71 neutralizing antibodies, indicating apparent but limited circulation of the virus in the region.
BACKGROUND AND OBJECTIVES: Human Enterovirus 71 (EV-A71) is the causative agent for many dermal to neurological diseases especially polio-like paralysis outbreaks around the world. This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT). MATERIALS AND METHODS: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complete titration to determine the exact titer of anti-EV-A71 antibodies. RESULTS: Of 547 samples, 310 (56.7%) were positive for EV-A71 neutralizing antibody. The presence of the antibody increased with age (p<0.001), and there was a significant statistical relationship between sex and the presence of antibody (p=0.009). CONCLUSION: Our results demonstrated an apparent but limited circulation of EV-A71 in our society. After the worldwide eradication of poliovirus, EV-A71 which can cause polio-likes syndrome, might be the new challenge for our health care system as regard more in depth research is however needed.
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Javadi et al. (2021) conducted a cross-sectional in Healthy individuals (n=547). Human Enterovirus 71 (EV-A71) exposure was evaluated on Presence of EV-A71 neutralizing antibody (titer ≥ 1:8). Human Enterovirus 71 (EV-A71) neutralizing antibodies were detected in 56.7% of healthy individuals in Iran, with seropositivity significantly increasing with age.
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