Serological Studies on the Pr(1)/Pr(2) Antigensusing Dog Erythrocytes

A heterogeneity of the Prx antigen is demonstrated using dog erythrocytes : Pr(1h)/Pr(1d). Pr(1h) is human erythrocyte-specific while Pr(1d) is also found on dog erythrocytes. Though also the Pr(2) antigen is found on dog red cells, it is independent of Pr(1d). Pr(2) is demonstrated on dog erythrocytes also after papainization while Pr(1d) is only found on untreated dog erythrocytes. The parallel of Prjh antigen deficiency and Pr(2) antigen increase on dog red cells in comparison with human red cells to human erythrocyte glycoproteins after periodate oxidation in comparison with untreated human red cell glycoproteins is stressed out and discussed.