Controlled Necrosis

This is the authors' abstract. We don't add key points for this paper.

Some necrosis mechanisms are considered. Although traditionally necrosis is considered as an uncontrolled and catastrophic cell death caused by intense damaging impacts, last data have shown that necrosis may occur in some physiological processes. Moreover, necrosis may be controlled by the intracellular signaling processes. For example, experiments with photodynamic treatment of neurons and surrounding glial cells have shown that increase in plasma membrane permeability leading to necrosis is controlled by neurotrophins, Ca 2+ -, cAMP-, and cGMP-dependent signaling pathways. An assortment of signaling proteins involved in these responses are different in neurons and glial cells. Thus, necrosis is uncontrolled under very strong impacts. However, necrotic processes induced by moderate impacts may be controlled by the cellular signaling system. Moreover, in some physiological situations necrosis may be performed according to the predetermined program.