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drive type 2 SLE manifestations and not just pain; central sensitization may also in fl uence perception of type 1 SLE manifestations. Behavioral responses to these manifestations may further perpetuate neuroim-mune dysfunction. Interoception represents a system by which physiological alternations (eg, in fl ammation) can be sensed and thereby in fl uence the patient experience of symptoms such as pain and fatigue. In some instances, the relationships are hypothetical and require greater experimental study. SLE, systemic lupus erythematosus; TLR, toll-like receptor.
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Pisetsky et al. (2025) studied this question.
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