Immunoneutralization of Circulating Inhibin in the Hypophysiotropically Clamped Male Rhesus Monkey (Macaca mulatto) Results in a Selective Hypersecretion of Follicle-Stimulating Hormone*

8 juvenile male rhesus monkeys (Macaca mulatta) with prematurely activated pituitary-testicular axis via chronic iv infusion of GnRH (0.1 microgram/min for 3 min every 3 h) for a minimum of 5 weeks.

Brief (30-min) iv infusion of an ovine antiserum to inhibin alpha-subunit (approximately 10 ml/kg BW) (n=4).

Comparable volume of a control ovine immune serum (n=4).

FSH response (concentrations of FSH in sequential plasma samples collected immediately before a GnRH infusion and for 3 h thereafter on days 0.5, 1, 2, 4, 8, and 16 after injection).surrogate