Reduced Left Ventricular Torsion Early After Myocardial Infarction Is Related to Left Ventricular Remodeling
Key result
Peak left ventricular torsion early after acute myocardial infarction independently predicted left ventricular remodeling at 6 months (OR 0.77; 95% CI 0.65-0.92; P=0.003).
Why the study?
Does peak LV torsion measured early after AMI predict LV remodeling at 6 months in patients with a first STEMI?
Population
120 patients with a first ST-segment elevation acute myocardial infarction treated with primary percutaneous…
Comparison
Assessment of peak left ventricular torsion by… vs Control subjects and internal comparison based…
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
May support post-STEMI risk stratification; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Observational (n=120)
Structured PICO
Does peak LV torsion measured early after AMI predict LV remodeling at 6 months in patients with a first STEMI?
P
Population
120 patients (mean age 59 years, 27% female) with a first ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention, followed for 6 months.
E
Exposure
Assessment of peak left ventricular (LV) torsion by speckle-tracking echocardiography 48 hours after AMI.
C
Comparator
Control subjects (for initial LV torsion comparison) and internal comparison based on LV remodeling status.
O
Outcome
Left ventricular remodeling at 6-month follow-up (defined as a ≥15% increase in LV end-systolic volume).surrogate
Main Result
Odds Ratio: 0.77 (95% CI 0.65–0.92)
p-value: p=0.003
Impaired peak LV torsion measured by speckle-tracking echocardiography early after a first STEMI is an independent predictor of adverse LV remodeling at 6 months.
Cite This Study
Nucifora et al. (2010) conducted an observational in First ST-segment elevation acute myocardial infarction (n=120). Peak left ventricular torsion vs. Control subjects was evaluated on Left ventricular remodeling (≥15% increase in LV end-systolic volume) (OR 0.77, 95% CI 0.65-0.92, p=0.003). Peak left ventricular torsion early after acute myocardial infarction independently predicted left ventricular remodeling at 6 months (OR 0.77; 95% CI 0.65-0.92; P=0.003).