Key result
Human voltage-gated proton channel activation involves extracellular amino acids when outer pH increases and cytoplasmic amino acids when inner pH decreases to extend interactions to the HG.
Computational simulations reveal the specific amino acid interaction networks involved in the pH-dependent gating of the human voltage-gated proton channel.
Extends molecular insights into Hv1 pH sensing; leaves open relevance to cardiovascular ion channel therapies.
1 activation, when outer pH increases, involves amino acids at the extracellular entrance of the channel that extend the network of interactions from the external solution down to the HG. Whereas, amino acids at the cytoplasmic entrance of the channel are involved in activation, when inner pH decreases, and in a network of interactions that extend from the cytoplasm up to the HG.
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Jardin et al. (2022) studied this question. Human voltage-gated proton channel activation involves extracellular amino acids when outer pH increases and cytoplasmic amino acids when inner pH decreases to extend interactions to the HG.
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