Population
Mammalian cells (HEK-293 or COS-7 cells) transfected with cDNA encoding human HVCN1 or mouse mVSOP ortholog
Comparison
Expression of human or mouse proton channel genes vs Native proton channels
Design
Preclinical
Authors
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Highlights discrepancies between expressed and native proton channels; leaves open their physiological relevance in animal models.
Expressed voltage-gated proton channels exhibit a functionally important -30 mV negative shift in voltage dependence compared to native channels, allowing for sustained inward proton currents.
Musset et al. (2008) studied this question.
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