Key result
Intravenous administration of Erythrina senegalensis methanol extract caused a dose-dependent reduction in mean arterial blood pressure by up to 24.42% at 44 mg/kg in normotensive rats.
The methanol extract of Erythrina senegalensis demonstrates dose-dependent hypotensive, negative chronotropic, and antioxidant effects in preclinical models, supporting its traditional use for hypertension.
Does not support clinical use; leaves open translation of Erythrina senegalensis hypotensive effects to humans.
The present study was undertaken to investigate the cardiovascular and the in vitro antioxidant activities of the methanol extract of the stem bark of Erythrina senegalensis (EMES), a plant used traditionally in Cameroon against arterial hypertension. The cardiovascular effects of EMES (11-44 mg/kg) were evaluated in vivo on normotensive rat arterial blood pressure and on rabbit’s electrocardiogram (5.5- 55 mg/kg) while the in vitro study (10-10 - 1 mg/ml) on myocardial contractile performance was evaluated on rat isolated heart. The antioxidant activities of EMES (1-1000 µg/ml) were investigated on 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2)-induced haemolysis, nitric oxide (NO) production, as well as its reducing power. The intravenous injection of EMES provoked in anaesthetized normotensive rats, a dose dependent immediate reduction in arterial hypertension. The mean arterial blood pressure dropped by 11.29, 19.84 and 24.42 % at respective doses of 11, 22 and 44 mg/kg. When administered intravenously in rabbit EMES significantly reduced the heart rate, amplitudes of P wave and QRS complex while significantly increasing the duration of the QT interval. EMES exhibited a concentration dependent reducing power, antiradical activity on DPPH (EC50 of 46.9 μg/ml) and a significant (p
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Atsamo et al. (2013) studied Normotensive. Methanol extract of the stem bark of Erythrina senegalensis (EMES) was evaluated on Mean arterial blood pressure. Intravenous administration of Erythrina senegalensis methanol extract caused a dose-dependent reduction in mean arterial blood pressure by up to 24.42% at 44 mg/kg in normotensive rats.
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