October 11, 1999The Journal of General PhysiologyOpen Access

Synergistic Activation of G Protein–Gated Inwardly Rectifying Potassium Channels by the βγ Subunits of G Proteins and Na+ and Mg2+ Ions

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Population

Native and recombinant G protein-gated inwardly rectifying potassium (GIRK) channels

Design

Preclinical

Authors

JPJérôme Petit-JacquesNew York University JSJin SuiChinese Academy of Sciences DLDiomedes E. LogothetisBoston University

Discussion

Member takes

Implication

Refines models of GIRK gating in vitro; leaves open effects on cardiac excitability in vivo.

Structured PICO

Population

Native and recombinant G protein-gated inwardly rectifying potassium (GIRK) channels

Intervention

Intracellular Mg2+ ions, Na+ ions, and G protein betagamma subunits in the presence of PIP2

Outcome

Channel activity (mean open time and single-channel conductance)surrogate

Synergistic interactions among Na+, Mg2+, and Gbetagamma subunits in the presence of PIP2 provide a rapid amplification mechanism for generating graded activity in GIRK channels, adjusting cellular excitability.

Cite This Study

Petit-Jacques et al. (1999) studied this question.

synapsesocial.com/papers/6a7c46fd7eebcb99d4a160f5 https://doi.org/10.1085/jgp.114.5.673

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Synergistic Activation of G Protein–Gated Inwardly Rectifying Potassium Channels by the βγ Subunits of G Proteins and Na+ and Mg2+ Ions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Synergistic Activation of G Protein–Gated Inwardly Rectifying Potassium Channels by the βγ Subunits of G Proteins and Na+ and Mg2+ Ions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider