Key result
The incidence of pulmonary embolism did not significantly differ between the ancestral strain (12%) and the Alpha (8%), Delta (11%), or Omicron (9%) variants.
Why the study?
Little information is available regarding the incidence and severity of pulmonary embolism across periods dominated by the ancestral SARS-CoV-2 strain versus the Alpha, Delta, and Omicron variants.
Does the COVID-19 variant (Alpha, Delta, Omicron vs ancestral) affect the incidence and severity of pulmonary embolism in patients undergoing CT pulmonary angiogram?
Cohort (n=720)
Does the COVID-19 variant (Alpha, Delta, Omicron vs ancestral) affect the incidence and severity of pulmonary embolism in patients undergoing CT pulmonary angiogram?
The incidence and severity of pulmonary embolism in COVID-19 patients remained consistent across the ancestral, Alpha, Delta, and Omicron variant periods.
Answers are grounded in this paper and cite their sources.
PE incidence consistent across variants supports uniform risk assessment; leaves open variant-specific prophylaxis needs.
Little information is available regarding incidence and severity of pulmonary embolism (PE) across the periods of ancestral strain, Alpha, Delta, and Omicron variants. The aim of this study is to investigate the incidence and severity of PE over the dominant periods of ancestral strain and Alpha, Delta, and Omicron variants. We hypothesized that the incidence and the severity by proximity of PE in patients with the newer variants and vaccination would be decreased compared with those in ancestral and earlier variants. Patients with COVID-19 diagnosis between March 2020 and February 2022 and computed tomography pulmonary angiogram performed within a 6-week window around the diagnosis (-2 to +4 weeks) were studied retrospectively. The primary endpoints were the associations of the incidence and location of PE with the ancestral strain and each variant. Of the 720 coronavirus disease 2019 patients with computed tomography pulmonary angiogram (58.6 ± 17.2 years; 374 females), PE was diagnosed among 42/358 (12%) during the ancestral strain period, 5/60 (8%) during the Alpha variant period, 16/152 (11%) during the Delta variant period, and 13/150 (9%) during the Omicron variant period. The most proximal PE (ancestral strain vs variants) was located in the main/lobar arteries (31% vs 6%-40%), in the segmental arteries (52% vs 60%-75%), and in the subsegmental arteries (17% vs 0%-19%). There was no significant difference in both the incidence and location of PE across the periods, confirmed by multivariable logistic regression models. In summary, the incidence and severity of PE did not significantly differ across the periods of ancestral strain and Alpha, Delta, and Omicron variants.
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Wada et al. (2023) conducted a cohort in COVID-19 (n=720). COVID-19 variants (Alpha, Delta, Omicron) vs. Ancestral strain was evaluated on Incidence and location of pulmonary embolism. The incidence of pulmonary embolism did not significantly differ between the ancestral strain (12%) and the Alpha (8%), Delta (11%), or Omicron (9%) variants.
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