Key result
Boosting with either the historical mRNA-1273 or the Omicron-matched mRNA-1273.529 vaccine increased neutralizing antibody titers and enhanced protection against B.1.1.529 infection in mice.
Why the study?
Does boosting with mRNA-1273 or mRNA-1273.529 improve neutralizing antibody responses and protection against SARS-CoV-2 B.1.1.529 infection in mice?
Does boosting with mRNA-1273 or mRNA-1273.529 improve neutralizing antibody responses and protection against SARS-CoV-2 B.1.1.529 infection in mice?
In mice, boosting with either the historical mRNA-1273 or an Omicron-matched mRNA-1273.529 vaccine enhances protection against the Omicron variant, with the matched vaccine providing modestly better neutralizing and virological outcomes.
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Does not yet guide booster strategies; leaves open translation from mice to humans.
Ying et al. (2022) studied SARS-CoV-2 B.1.1.529 (Omicron) infection. mRNA-1273 or mRNA-1273.529 vaccine vs. Control mRNA vaccine was evaluated on Neutralizing antibody titers and viral RNA levels in respiratory tract. Boosting with either the historical mRNA-1273 or the Omicron-matched mRNA-1273.529 vaccine increased neutralizing antibody titers and enhanced protection against B.1.1.529 infection in mice.
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