Key result
Levosimendan significantly increased renal blood flow by 12% and glomerular filtration rate by 21% (p<0.05) compared to placebo early after cardiac surgery with cardiopulmonary bypass.
Why the study?
Does levosimendan improve renal blood flow and glomerular filtration rate in postcardiac surgery patients?
Population
30 postcardiac surgery patients (after cardiopulmonary bypass) in a cardiothoracic ICU of a tertiary center.
Comparison
Levosimendan 0.1 µg/kg/min continuous infusion… vs Placebo.
Design
RCT, randomized, placebo-controlled
Follow-up
4-6 hours after surgery
Authors
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May support levosimendan for renal protection after cardiac surgery; extends hemodynamic RCT data to renal perfusion.
RCT (n=30)
Randomized
No
Does levosimendan improve renal blood flow and glomerular filtration rate in postcardiac surgery patients?
Effect estimate: 12% increase in RBF, 21% increase in GFR
p-value: p=<0.05
Levosimendan increases renal blood flow and glomerular filtration rate without jeopardizing renal oxygenation early after cardiac surgery with cardiopulmonary bypass.
Bragadottir et al. (2013) conducted an RCT in Postcardiac surgery (n=30). Levosimendan vs. Placebo was evaluated on Renal blood flow and glomerular filtration rate (12% increase in RBF, 21% increase in GFR, p=<0.05). Levosimendan significantly increased renal blood flow by 12% and glomerular filtration rate by 21% (p<0.05) compared to placebo early after cardiac surgery with cardiopulmonary bypass.
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