The Importance Of Galectin 3 For Risk Stratification And Prognosis In Hypertrophic Cardiomyopathy

Objective: Galectin-3 levels were found to be associated with worse prognosis in various cardiac disorders.The aim of the study was to assess the relationship between serum galectin-3 levels and prognosis among HCM patients.Material and Methods: This study included 107 consecutive patients with HCM.Galectin-3 levels were evaluated in all participants and the HCM Risk-SCD calculated in patients with HCM for each patient.Results: The low galectin-3 and high galectin-3 groups showed significant differences in NYHA class, the HCM Risk SCD, the HCM Risk SCD (>6%), interventricular septum thickness, left ventricular mass(LVM), and LVM index, and percentage of ventricular extra systole, ventricular tachycardia, cardiopulmonary resuscitation, ICD implantation, shock, admitted hospital with heart failure symptoms into two groups(all p<0.05).The low galectin-3 HCM patients (n = 62) had galectin-3 levels of 4.720±2.202ng/ml and the high galectin-3 HCM patients (n = 45) had galectin-3 levels of 7.943±1.618ng/ml(p<0.001).Both in the univariate and multivariate analysis, galectin-3 determined that the HCM Risk SCD is an independent predictor of high-risk(p<0.001).In ROC curve analysis, a galectin-3 >6.324 ng/ml was identified as an effective cut-off point in the HCM Risk SCD for HCM (area under curve = 0.878, 95% CI=0.815-0.942,p <0.001).A galectin-3 value of more than 6.324 ng/ml yielded a with sensitivity, specificity, positive predictive value and negative predictive value of, 83%, 82%, 73%, 93%.