Acute Massive Digitoxin Poisoning: Report of a Case and Review of the Literature

Case Reports1 May 1957ACUTE MASSIVE DIGITOXIN POISONING: REPORT OF A CASE AND REVIEW OF THE LITERATUREGORDON G. BERGY, M.D., EMILY B. FERGUS, M.D., ROBERT A. BRUCE, M.D., F.A.C.P.GORDON G. BERGY, M.D., EMILY B. FERGUS, M.D., ROBERT A. BRUCE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-5-964 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe opportunity to observe myocardial and metabolic responses to massive digitoxin poisoning was recently afforded us by a patient who ingested 75 tablets of digitoxin with suicidal intent. The salient clinical and electrocardiographic manifestations of previously reported cases of poisoning from digitalis and related glycosides are summarized in table 1.1-5In addition, another case, not reported in the literature, has been included through the kindness of Dr. Paul N. G. Yu, of Rochester, N. Y.6 Our case is presented to show serial electrocardiographic changes, metabolic responses and pathologic examination of the heart obtained at autopsy.CASE REPORTA 61 year...Bibliography1. TomazewskiLapa DWDW: Un cas d'intoxication digitalique, Arch. d. mal. du cœur 29: 196, 1936. Google Scholar2. McGuireRichards JCE: Fatal digitalis poisoning occurring in a normal individual, Am. Heart J. 12: 109, 1936. CrossrefGoogle Scholar3. DuvoirPolletDesoilleGaultier MLHM: Deux cas d'intoxication par la digitaline. Etude electrocardiographique, Bull. et mém. Soc. méd. d. hôp. de Paris 54: 159, 1938. Google Scholar4. BickelPlattnerEdelstein GHH: Intoxication digitalique massive terminie par la guerison, Arch. d. mal. du cœur 44: 61, 1951. MedlineGoogle Scholar5. VuleticIvancic VR: A propos d'un cas d'intoxication aigue et massive par la digitale, Arch. d. mal. du cœur 45: 853, 1952. MedlineGoogle Scholar6. Yu PN: Personal communication, 1954. Google Scholar7. DearingBarnesEssex WHARHE: Experiments with calculated therapeutic and toxic doses of digitalis. I. Effects on myocardial cellular structure, Am. Heart J. 25: 648, 1943. CrossrefGoogle Scholar8. La Due JS: Myocardial necrosis and fibrosis resulting from the administration of massive doses of a cardiac glycoside, J. Pharmacol. and Exper. Therap. 76: 1, 1952. Google Scholar9. TravellGoldModellAuerbach JHWO: Study of cardiac hemorrhages caused by digitalis glycosides, Federation Proc. 1: 170, 1942. Google Scholar10. LownLevine BSA: Current concepts in digitalis therapy. Part II, New England J. Med. 250: 819, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington*Received for publication June 25, 1956.From the Cardiology Division, University of Washington, Seattle, Washington.Requests for reprints should be addressed to Gordon G. Bergy, M.D., Hall Health Center, University of Washington, Seattle 5, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by2. Report of a Suicidal Digoxin Intoxication: A Case ReportAcute digitalis poisoning: The role of intravenous magnesium sulfateUse of amiodarone and digoxin specific Fab antibodies in digoxin overdosage.DigitalisFatal digoxin overdoseLeiomyosarcomatosis of probable uterine origin with long survival--a case reportDigitalis intoxication and poisoningPRODUCTION AND PROPERTIES OF DIGOXIN-SPECIFIC ANTIBODIESAssays of digitalis in the bloodTHE CLINICAL VALUE OF SERUM DIGITALIS GLYCOSIDE CONCENTRATIONS IN THE EVALUATION OF DRUG TOXICITYSuicidal and Accidental Digoxin IngestionFOUR CASES OF MASSIVE DIGITALIS POISONINGRecognition and therapy of digitalis toxicityRecognition and therapy of digitalis toxicityAccidental digitalis intoxication in childrenDigitalis intoxication in premature infantsThe toxicology of digitalis∗Therapie der HerzinsuffizienzTreatment of Acute Massive Digitalis Poisoning by Administration of a Chelating AgentAcetyl strophanthidin sensitivity in dogs with congestive heart failureAccidental digitoxin poisoning in children 1 May 1957Volume 46, Issue 5Page: 964-976KeywordsAutopsyDrugsElectrocardiographyExcretionGlycosidesHeartIschemiaMyocarditisPneumoniaTachycardia ePublished: 1 December 2008 Issue Published: 1 May 1957 PDF downloadLoading ...