What question did this study set out to answer?

To evaluate how thyroid dysfunction influences the metabolism, serum levels, turnover rates, and excretion of digoxin.

March 1, 1966Annals of Internal Medicine

Digoxin Metabolism in Hypo- and Hyperthyroidism

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Authors

JDJames E. DohertySage Therapeutics (United States)

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Implication

Pharmacokinetic study reveals altered digoxin turnover in thyroid disease, indicating why hyperthyroid patients require higher doses and hypothyroid patients need lower doses.

Key Points

To evaluate how thyroid dysfunction influences the metabolism, serum levels, turnover rates, and excretion of digoxin.
Administered tritiated (radioactive) digoxin to patients with hyperthyroidism, hypothyroidism (myxedema), and euthyroid controls.
Assessed serum concentrations, metabolic turnover, and excretion patterns of labeled digoxin following administration.
Hyperthyroid status accelerated digoxin clearance and lowered serum concentrations, explaining why higher doses are required to control ventricular rate in atrial fibrillation.
Hypothyroid status reduced digoxin turnover and excretion, leading to elevated serum concentrations and increased sensitivity to standard therapeutic doses.

Cite This Study

James E. Doherty (1966) studied this question.

synapsesocial.com/papers/6a7cebe7b57d2d01705e0107 https://doi.org/10.7326/0003-4819-64-3-489

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Implication

Pharmacokinetic study reveals altered digoxin turnover in thyroid disease, indicating why hyperthyroid patients require higher doses and hypothyroid patients need lower doses.

Digoxin Metabolism in Hypo- and Hyperthyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

Digoxin Metabolism in Hypo- and Hyperthyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

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