Why the study?
Does the ischemic threshold exhibit a circadian pattern that relates to the frequency of ischemic episodes in patients with stable coronary disease?
Does the ischemic threshold exhibit a circadian pattern that relates to the frequency of ischemic episodes in patients with stable coronary disease?
The morning increase in ischemic episodes is primarily driven by increased myocardial oxygen demand, whereas nighttime ischemia may relate to reduced coronary flow from increased coronary tone.
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May inform symptom monitoring timing in stable CAD; extends circadian ischemia research but requires prospective validation.
Benhorin et al. (1993) studied this question.
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