What question did this study set out to answer?

To determine how macrophage-specific Yes-associated protein (YAP) regulates macrophage polarization, inflammatory signaling, and gut microbial balance in inflammatory bowel disease.

April 1, 2019Cell ReportsOpen Access

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

View Full Paper

Ask AI

Bookmark

To determine how macrophage-specific Yes-associated protein (YAP) regulates macrophage polarization, inflammatory signaling, and gut microbial balance in inflammatory bowel disease.
Examined macrophage polarization under interleukin-4/interleukin-13 (M2-inducing) and lipopolysaccharide/interferon-γ (M1-inducing) conditions in the presence of YAP.
Assessed intestinal disease progression, antimicrobial peptide production, and gut microbiota profiles modulated by macrophage YAP.
Macrophage YAP exacerbates inflammatory bowel disease, accompanied by altered gut microbiota composition and the induction of antimicrobial peptides.
YAP inhibits interleukin-4/interleukin-13-mediated M2 macrophage polarization while enhancing lipopolysaccharide/interferon-γ-driven M1 activation to induce interleukin-6.
Expression of YAP is differentially regulated during the separate induction stages of M1 versus M2 macrophages.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Experimental study demonstrates that macrophage YAP aggravates inflammation and microbiome disruption in inflammatory bowel disease models, suggesting cell-specific targeting is necessary.

Cite This Study

Zhou et al. (2019) studied this question.

synapsesocial.com/papers/6a7c53620449e558d7c2e7e2 https://doi.org/10.1016/j.celrep.2019.03.028

View Full Paper

Ask AI

Bookmark

Implication

Experimental study demonstrates that macrophage YAP aggravates inflammation and microbiome disruption in inflammatory bowel disease models, suggesting cell-specific targeting is necessary.

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

Key Points

Discussion

Implication

Cite This Study

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider