Control mechanisms of lymphocyte traffic. Modification of the traffic of ⁵¹ Cr‐Labeled mouse lymph node cells by treatment with plant lectins in intact and splenectomized hosts

The results of a study of the effect of treatment of purified or mixed lymphocyte populations with concanavalin A (Con A), chymotrypsinized Con A and phytohemagglutinin on their distribution in syngeneic intact and splenectomized hosts after i. v. injection are reported. The currently held view that lymphocyte traffic is controlled by a specific interaction between the sugars on the surface of the lymphocytes and the post‐capillary venule in the lymph nodes is questioned and an alternative explanation offered for the demonstrable decrease in lymph node entry in intact recipients of lymphocytes pretreated with plant lectins.