Key result
Novel 31P-MRS technique cuts myocardial creatine kinase measurement time by ~82% in vivo.
Answers are grounded in this paper and cite their sources.
In the heart, the creatine kinase (CK) system plays an important role in the cascade of ATP production, transportation, and utilization. The forward pseudo-first-order rate constant for the CK reaction can be measured noninvasively by the (31)P-magnetic resonance (MR) spectroscopy magnetization saturation transfer (MST) techniques. However, the measurement of MST in the in vivo heart is limited by the lengthy data acquisition time, especially for studies requiring spatial localization. This technical report presents a new method for measuring ATP production rate via CK that can reduce the MST data acquisition time by 82%. This method is validated using an in vivo pig model to evaluate the forward pseudo-first-order rate constant of myocardial CK reaction noninvasively.
No takes yet. Share an insight, caveat, or question.
Xiong et al. (2009) studied this question. New 31P-MR spectroscopy magnetization saturation transfer (MST) method vs. Conventional 31P-MR spectroscopy MST technique was evaluated on Magnetization saturation transfer (MST) data acquisition time for measuring ATP production rate via creatine kinase (82% reduction). A new 31P-MR spectroscopy magnetization saturation transfer method reduced data acquisition time by 82% when measuring the myocardial creatine kinase reaction rate in an in vivo pig model.
Synapse has enriched 10 related papers. Consider them for comparative context: