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September 1, 2001Biochemical JournalOpen Access

Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide

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Population

Wild-type and genetically modified (knockout) mice in which the gene encoding NPRA has been disrupted

Comparison

NPRA gene disruption (knockout) vs Wild-type mice

Design

Preclinical

Authors

MGMichael F. GoyUniversity of North Carolina at Chapel HillPOPaula M. OliverChildren's Hospital of PhiladelphiaKPKit E. PurdyUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Suggests a novel BNP-preferring receptor in testis and adrenal; leaves open its identity and physiologic relevance in humans.

Structured PICO

P
Population
Wild-type and genetically modified (knockout) mice in which the gene encoding NPRA has been disrupted
I
Intervention
NPRA gene disruption (knockout)
C
Comparator
Wild-type mice
O
Outcome
ANP- and BNP-stimulatable guanylate cyclase (GC) activities and cGMP synthesis in isolated tissuessurrogate

Demonstrates the potential existence of a novel natriuretic peptide receptor that preferentially binds BNP over ANP in specific tissues.

Cite This Study

Goy et al. (2001) studied this question.

synapsesocial.com/papers/6a7c5730d501feb4353bedc0https://doi.org/10.1042/0264-6021:3580379
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human natriuretic peptide receptor-A guanylyl cyclase. Hormone cross-linking and antibody reactivity distinguish receptor glycoforms.1992 · 55 citations
  2. 2C-TYPE NATRIURETIC PEPTIDE (CNP) IN RATS AND HUMANS1991 · 301 citations
  3. 3NPR-A–Deficient Mice Show Increased Susceptibility to Hypoxia-Induced Pulmonary Hypertension1999 · 83 citations
  4. 4Inhibition by Cardiac Natriuretic Peptides of Rat Vascular Endothelial Cell Migration1995 · 11 citations
  5. 5The Family of Guanylyl Cyclase Receptors and Their Ligands1994 · 340 citations