The role of the renin–angiotensin–aldosterone system in cardiovascular progenitor cell function
Population
Cardiovascular progenitor cells in the context of cardiovascular disease
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Heterogeneous RAAS effects on progenitor cells warrant clinical caution; leaves open mediator-specific targeting for future trials.
Structured PICO
P
Population
Cardiovascular progenitor cells (mesenchymal stem cells, haematopoietic progenitor cells, and endothelial progenitor cells) in the context of cardiovascular disease (myocardial infarction, hypertension, ischaemia)
I
Intervention
Modulation of the renin-angiotensin-aldosterone system (RAAS) using angiotensin II type 1 receptor antagonists, angiotensin-converting enzyme inhibitors, and other mediators (angiotensin II, angiotensin-(1-7), aldosterone, bradykinin, Ac-SDKP)
O
Outcome
Progenitor cell levels and function
This review highlights the complex and variable effects of RAAS modulation on cardiovascular progenitor cells, suggesting that different mediators and disease models significantly influence regenerative cell function.
Cite This Study
Qian et al. (2009) studied this question.