Study of ¹³C–¹⁹F and ¹H–¹⁹F couplings in some fluorinated aromatic compounds using two‐dimensional ¹³C–¹H chemical shift correlation spectroscopy with proton homonuclear decoupling

The magnitudes and relative signs of 13 C– 19 F and 1 H– 19 F coupling constants in 6‐F‐indole, 5‐ and 6‐F‐tryptamine, 5‐F‐indole‐3‐carboxaldehyde, 2‐ and 4‐F‐biphenyl, droperidol, flusperilene, 1‐F‐naphthalene and 3‐F‐fluroanthene (F = fluoro) have been determined using two‐dimensional 13 C– 1 H chemical shift correlation spectroscopy with proton homonuclear decoupling. Except for one long‐range 1 H– 19 F coupling constant, all the other observed 1 H– 19 F couplings in these compounds were found to be of the same sign as the corresponding 13 C– 19 F coupling constants. The variation of the magnitude of tlfe coupling constants due to substitution is relatively insignificant.