Key result
Dorsal root ganglion stimulation significantly reduced sympathetic nerve firing frequency and blood pressure compared to OFF stimulation, particularly with left-sided stimulation.
Why the study?
It was hypothesized that dorsal root ganglion stimulation would reduce sympathetic nerve activity and alter hemodynamic variables.
Does dorsal root ganglion stimulation reduce sympathetic nerve activity and blood pressure?
Does dorsal root ganglion stimulation reduce sympathetic nerve activity and blood pressure?
Dorsal root ganglion stimulation reduces sympathetic nerve activity and blood pressure, suggesting potential as a neuromodulatory treatment for autonomic disorders such as hypertension or heart failure.
Suggests neuromodulation target for hypertension; hypothesis-generating and requires prospective trials before any clinical consideration.
This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity during ON and OFF stimulation of the DRG while measuring hemodynamic parameters. DRG stimulation significantly reduced the firing frequency of sympathetic nerves, as well as significantly reducing blood pressure, with greater reductions evident when stimulation was left-sided. Left-sided DRG stimulation lowers sympathetic nerve activity, leading to long-term phenotypic changes. This raises the potential of DRG stimulation being used to treat de novo autonomic disorders such as hypertension or heart failure.
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Sverrisdóttir et al. (2020) studied this question. Dorsal root ganglion (DRG) stimulation vs. OFF stimulation was evaluated on Sympathetic nerve activity and blood pressure. Dorsal root ganglion stimulation significantly reduced sympathetic nerve firing frequency and blood pressure compared to OFF stimulation, particularly with left-sided stimulation.
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