Key result
The retrotrapezoid nucleus may contain the most important central chemoreceptors, supporting the specialized chemoreceptor theory over the distributed chemoreception theory.
Design
Review
Authors
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May inform chemoreflex models in HF; leaves open confirmation of retrotrapezoid dominance before clinical translation.
This review supports the specialized chemoreceptor theory, proposing that the retrotrapezoid nucleus contains the primary central chemoreceptors responsible for the central chemoreflex.
Guyenet et al. (2008) conducted a review in Central chemoreception. The retrotrapezoid nucleus may contain the most important central chemoreceptors, supporting the specialized chemoreceptor theory over the distributed chemoreception theory.
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