Key result
Arterial stiffness assessed by pulse wave velocity did not differ significantly between older people with Alzheimer's disease (10.7 m/s), vascular dementia (11.3 m/s), and controls (10.0 m/s; p>0.05).
Why the study?
Does arterial stiffness differ between older people with Alzheimer's disease, vascular dementia, and controls?
Cross-Sectional (n=72)
Does arterial stiffness differ between older people with Alzheimer's disease, vascular dementia, and controls?
Arterial stiffness assessed by pulse wave velocity did not significantly differ between older patients with Alzheimer's disease, vascular dementia, and controls.
Similar arterial stiffness across groups does not support subtype differentiation; leaves open longitudinal or mechanistic roles in dementia.
Alzheimer’s disease and vascular dementia are the most common causes of cognitive dysfunction among older people. Vascular damage plays a role in the etiopathogenesis of both Alzheimer’s disease and vascular dementia. Arterial stiffness is a marker of vascular damage. The aim of this study was to compare arterial stiffness between Alzheimer’s disease, vascular dementia and controls without memory complaints. A total of 72 older people (Alzheimer’s disease=22, vascular dementia=28, controls=22) were included in the study. Demographic data were obtained and ambulatory blood pressure monitoring was applied. Arterial stiffness was evaluated with carotid to femoral pulse wave velocity measurements. Mean pulse wave velocity was 10.7±2.0 m/s, 11.3±3.1 m/s, and 10.0±3.1 m/s in Alzheimer’s disease, vascular dementia and controls, respectively (p>0.05).Arterial stiffness assessed by pulse wave velocity might play a role in the development of vascular dementia and Alzheimer's disease, but further evidence is needed to confirm this relationship.
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Yalçın et al. (2015) conducted a cross-sectional in Alzheimer's disease and vascular dementia (n=72). Alzheimer's disease and vascular dementia vs. Controls without memory complaints was evaluated on Arterial stiffness (carotid to femoral pulse wave velocity) (p=>0.05). Arterial stiffness assessed by pulse wave velocity did not differ significantly between older people with Alzheimer's disease (10.7 m/s), vascular dementia (11.3 m/s), and controls (10.0 m/s; p>0.05).
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